「2014年度以降」

• MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility.
  Hirata H, Ku WC, Yip AK, Ursekar CP, Kawauchi K, Roy A, Guo AK, Vedula SR, Harada I, Chiam KH, Ishihama Y, Lim CT, Sawada Y, Sokabe M
  J Cell Sci. 2016 Aug 15. pii: jcs.189415.　

• Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration.
  Zhao Z, Tan SH, Machiyama H, Kawauchi K, Araki K, Hirata H, Sawada Y.
  Biology Open 4 pp1569-1575 (2016)
• Novel localization of formin mDia2: importin beta;-mediated delivery to and retention at the cytoplasmic side of nuclear envelopeShao X, Shao Kawauchi K, Shivashankar GV, Bershadsky DA
  Biology Open 4 pp1569-1575 (2015)
• p53 regulates cytoskeleton remodeling to suppress tumor progression
  Araki K, Ebata T, Guo K A, Tobiume K, Wolf JS, Kawauchi K*　　　　　　　　　　　　　　　　　　　　　Cellular and Molecular Life Sciences 72 pp4077-4094 (2015)
• Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force
  Yu CH, Rafiq NB, Cao F, Zhou Y, Krishnasamy A, Biswas K, Ravasio A, Chen Z, Wang YH, Kawauchi K, Gareth J, Sheetz M
  Nature Comm. 6, 8672 (2015)
• p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion
  Yamauchi S, Hou YY, Guo K A, Hirata H, Nakajima W, Yap AK., Yu CH, Harada I, Chaim KW, Sawada Y, Kawauchi K*.
  J. Cell Biology 204 pp1191-1207 (2014) *corresponding author
• Understanding p53: new insights into tumor suppression
  Kawauchi K* and Wolf JS.
  Expert Review of Anticancer Therapy 14 pp1101-1103 (2014)
• Loss of p53 enhances NF-kappaB-dependent lamellipodia formation
  Guo K A, Hou YY, Hirata H, Yamauchi S, Yap AK, Chaim KW, Sawada Y, Kawauchi K*.
  J. Cell Physiology 229 pp696-704 (2014)
• Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers.
  Higuchi S, Watanabe T, Kawauchi K, Ichimura T, Fujita H.
  J. Biosci. Bioengin. 117 pp749-755 (2014)

「2014年度以前」

• Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization
  Araki K, Kawauchi K, Hirata H, Yamamoto M, Taya Y.
  eLife 2 e01228 (2013)
• Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis.
  Yamauchi S, Kawauchi K, Sawada Y.
  FEBS Letters 586 pp3229-3235 (2012)
• p130Cas-dependent actin remodelling regulates myogenic differentiation.
  Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y.
  Biochem. J. 445 pp323-332 (2012)
• Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts.
  Watanabe TM, Higuchi S, Kawauchi K, Tsukasaki Y, Ichimura T, Fujita H.
  Biochem. Biophys. Res. Commun. 418 pp742-747 (2012)
• The molecular mechanism of glucose metabolism hampered by p53 tumor suppressor protein.
  Kawauchi K*.
  J Nippon Med Sch. 77 pp48-49 (2010)
• Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3.
  Ando M, Uehara I, Kogure K, Asano Y, Nakajima W, Abe Y, Kawauchi K, Tanaka N.
  J. Nippon. Med. Sch. 77 pp97-105 (2010)
• Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.
  Kawauchi K, Araki K, Tobiume K, Tanaka N.
  Proc. Natl. Acad. Sci. U S A. 106 pp3431-3436 (2009)
• IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.
  Araki K, Kawauchi K, Tanaka N.
  Oncogene 112 pp5878-5884 (2008)
• Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells.
  Kawauchi K*, Tobiume K, Iwashita K, Inagaki H, Morikawa T, Shibukawa Y, Moriyama Y, Hirata H, Kamata H.
  Biosci. Biotech. Biochem. 72 pp1564-1570 (2008)
• Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.
  Kawauchi K, Araki K, Tobiume K, Tanaka N.
  Biochem. Biophys. Res. Commun. 372 pp137-141 (2008)
• p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
  Kawauchi K, Araki K, Tobiume K, Tanaka N.
  Nature Cell Biol. 10 pp611-618 (2008)
• Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
  Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N.
  Proc. Natl. Acad. Sci. U S A. 105 pp4838-4843 (2008)
• Suppression of AP-1 activity by cycloprodigiosin hydrochloride.
  Kawauchi K*, Tobiume K, Kaneko S, Kaneshiro K, Okamoto S, Ueda E, Kamata H, 　　　　　　　Moriyama Y, Hirata H.
  Biol. Pharm. Bull. 30 pp1792-1795 (2007)
• Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
  Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K.
  Biochemistry 44 pp3891-3898 (2005)
• Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta.
  Teshima S, Nakanishi H, Kamata K, Kaibori M, Kwon AH, Kamiyama Y, Nishizawa M, Ito S, Okumura T.
  Nitric Oxide:Biol. Chem.11 pp9-16 (2004)
• Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
  Maeno K, Sada K, Kyo S, Miah SM, Kawauchi-Kamata K, Qu X, Shi Y, Yamamura H.
  J. Biol. Chem. 278 pp24912-24920 (2003)
• Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation.
  Kyo S, Sada K, Qu X, Maeno K, Miah SM, Kawauchi-Kamata K, Yamamura H.
  Genes to Cells 8 pp825-836 (2003)
• Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops.
  Kamata H, Manabe T, Oka Si, Kamata K, Hirata H.
  FEBS Letters 519 pp231-237(2002)
• Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cells.
  Yamamoto D, Tanaka K, Nakai K, Baden T, Inoue K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Morikawa S, Inubushi T, Hioki K.
  Breast Cancer Research and Treatment 72 pp1-10 (2002)
• Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB.
  Kamata K, Okamoto S, Oka S, Kamata H, Yagisawa H, Hirata H.
  FEBS Letters 507 pp50774-50780 (2001)
• Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon　　　　　　 cancer cell lines in vitro.
  Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Nakai K, Baden T, Kamata K, Hirata H, 　　　Watanabe T, Inoue K.
  Oncology Reports 8 pp821-824 (2001)
• Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation 　　　　　　in HL-60 cells.
  Yamamoto D, Uemura Y, Tanaka K, Nakai K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Hioki K.
  International Journal of Cancer 88 pp121-128 (2000)
• Demonstration of Cl- requirement for inhibition of vacuolar acidification by cycloprodigiosin in situ.
  Nakayasu T, Kawauchi K, Hirata H, Shimmen T.
  Plant & Cell Physiol. 41 pp857-863 (2000)
• N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases.
  Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H.
  FEBS Letters 472 pp196-202 (2000)
• Cycloprodigiosin hydrochloride, a new H(+)/Cl(-) symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma 　　xenografts in nude mice.
  Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Tsubura A, Kamata K, Hirata H, Yamamoto A, 　Kano H, Seki T, Inoue K.
  Hepatology 30 pp894-902 (1999)
• Cycloprodigiosin uncouples H+-pyrophosphatase of plant vacuolar membranes in the presence of chloride ion.
  Maeshima, M, Nakayasu, T, Kawauchi, K, Hirata, H, Shimmen, T.
  Plant & Cell Physiol. 40 pp439-442 (1999)
• Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent.
  Kim HS, Hayashi M, Shibata Y, Wataya Y, Mitamura T, Horii T, Kawauchi K, Hirata H, Tsuboi S, Moriyama Y.
  Biol. Pharm. Bull. 22 pp532-534 (1999)
• Cycloprodigiosin hydrochloride inhibits acidification of plant vacuole.
  Nakayasu, T, Kawauchi, K, Hirata, H, Shimmen, T.
  Plant & Cell Physiol. 40 pp143-148 (1999)
• A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans.
  Kawauchi K, Shibutani K, Yagisawa H, Kamata H, Nakatsuji S, Anzai H, Yokoyama Y, Ikegami Y, Moriyama Y, Hirata H.
  Biochem. Biophys. Res. Commun. 237 pp543-547 (1997)

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著書

• ゼロからはじまるバイオ実験マスターコース３―細胞培養トレーニング
  西方敬人、川上純司、藤井敏司、長濱宏治、川内敬子

• RASによるがん悪性化に、p53を介したアクチン細胞骨格の変化がブレーキをかける道筋を解明！
  川内敬子